CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity

Variations in the Crumbs homolog-1 (<i>CRB1</i>) gene are associated with a wide variety of autosomal recessive retinal dystrophies, including early onset retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA). CRB1 belongs to the Crumbs family, which in mammals includes CRB2 and...

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Bibliographic Details
Main Authors: C. Henrique Alves, Nanda Boon, Aat A. Mulder, Abraham J. Koster, Carolina R. Jost, Jan Wijnholds
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
crumbs complex
crumbs homolog-1
Leber congenital amaurosis
photoreceptors
retina
retinal degeneration
retinitis pigmentosa
rod photoreceptors
Online Access:https://www.mdpi.com/1422-0067/20/17/4069

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https://www.mdpi.com/1422-0067/20/17/4069

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