METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

Abstract Background METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder cancer, METTL3 could promote the bladder cancer progression via AFF4/NF...

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Bibliographic Details
Main Authors: Jie Han, Jing-zi Wang, Xiao Yang, Hao Yu, Rui Zhou, Hong-Cheng Lu, Wen-Bo Yuan, Jian-chen Lu, Zi-jian Zhou, Qiang Lu, Ji-Fu Wei, Haiwei Yang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Molecular Cancer
Subjects:
METTL3
Bladder cancer
m6A
miR221/222
PTEN
Online Access:http://link.springer.com/article/10.1186/s12943-019-1036-9

Internet

http://link.springer.com/article/10.1186/s12943-019-1036-9

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