Human mucosal associated invariant T cells detect bacterially infected cells.

Human mucosal associated invariant T cells detect bacterially infected cells.

Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+...

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Bibliographic Details
Main Authors: Marielle C Gold, Stefania Cerri, Susan Smyk-Pearson, Meghan E Cansler, Todd M Vogt, Jacob Delepine, Ervina Winata, Gwendolyn M Swarbrick, Wei-Jen Chua, Yik Y L Yu, Olivier Lantz, Matthew S Cook, Megan D Null, David B Jacoby, Melanie J Harriff, Deborah A Lewinsohn, Ted H Hansen, David M Lewinsohn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2893946?pdf=render

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http://europepmc.org/articles/PMC2893946?pdf=render

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