The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy

The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy

Inflammation is a central aspect of tumour biology and can contribute significantly to both the origination and progression of tumours. The NFκB pathway is one of the most important signal transduction pathways in inflammation and is, therefore, an excellent target for cancer therapy. In t...

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Bibliographic Details
Main Authors: Mario Joachim Johannes Scheurer, Roman Camillus Brands, Mohamed El-Mesery, Stefan Hartmann, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Axel Seher
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
HNSCC
NFκB
inhibitor
TPCA1
apoptosis
inflammation
TNFα
FasL
Online Access:http://www.mdpi.com/1422-0067/20/6/1306

Internet

http://www.mdpi.com/1422-0067/20/6/1306

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