The Sirt1/P53 Axis in Diabetic Intervertebral Disc Degeneration Pathogenesis and Therapeutics

The Sirt1/P53 Axis in Diabetic Intervertebral Disc Degeneration Pathogenesis and Therapeutics

Intervertebral disc degeneration (IDD) is one of the major causes of low back pain. Diabetes is a risk factor for IDD and may aggravate IDD in rats; however, the mechanism is poorly understood. Previously, we demonstrated that apoptosis and senescence were increased in diabetic nucleus pulposus (NP)...

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Main Authors: Zengjie Zhang, Jialiang Lin, Majid Nisar, Tingting Chen, Tianzhen Xu, Gang Zheng, Chenggui Wang, Haiming Jin, Jiaoxiang Chen, Weiyang Gao, Naifeng Tian, Xiangyang Wang, Xiaolei Zhang
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2019/7959573

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http://dx.doi.org/10.1155/2019/7959573

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