Hypoproliferative human neural progenitor cell xenografts survived extendedly in the brain of immunocompetent rats

Hypoproliferative human neural progenitor cell xenografts survived extendedly in the brain of immunocompetent rats

Abstract Background There is a huge controversy about whether xenograft or allograft in the “immune-privileged” brain needs immunosuppression. In animal studies, the prevailing sophisticated use of immunosuppression or immunodeficient animal is detrimental for the recipients, which results in a shor...

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Bibliographic Details
Main Authors: Chunhua Liu, Xiaoyun Wang, Wenhao Huang, Wei Meng, Zhenghui Su, Qi Xing, Heng Shi, Di Zhang, Min Zhou, Yifan Zhao, Haitao Wang, Guangjin Pan, Xiaofen Zhong, Duanqing Pei, Yiping Guo
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Stem Cell Research & Therapy
Subjects:
Human neural progenitor cells
Xenograft
Immuno-rejection
Hypoproliferation
Immune privilege
Microglia
Online Access:https://doi.org/10.1186/s13287-021-02427-1

Internet

https://doi.org/10.1186/s13287-021-02427-1

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