The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts

The Orphan Cytokine Receptor CRLF3 Emerged With the Origin of the Nervous System and Is a Neuroprotective Erythropoietin Receptor in Locusts

The orphan cytokine receptor-like factor 3 (CRLF3) was identified as a neuroprotective erythropoietin receptor in locust neurons and emerged with the evolution of the eumetazoan nervous system. Human CRLF3 belongs to class I helical cytokine receptors that mediate pleiotropic cellular reactions to i...

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Bibliographic Details
Main Authors: Nina Hahn, Luca Büschgens, Nicola Schwedhelm-Domeyer, Sarah Bank, Bart R. H. Geurten, Pia Neugebauer, Bita Massih, Martin C. Göpfert, Ralf Heinrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuroprotection
erythropoietin
cytokine receptor
Locusta migratoria
soaking RNA interference
nervous system
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00251/full

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https://www.frontiersin.org/article/10.3389/fnmol.2019.00251/full

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