Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis

Activated CAMKKβ-AMPK signaling promotes autophagy in a spheroid model of ovarian tumour metastasis

Abstract Background A hallmark of epithelial ovarian cancer (EOC) metastasis is the process of spheroid formation, whereby tumour cells aggregate into 3D structures while in suspension in the peritoneal cavity. EOC spheroids are subjected to bioenergetic stress, thereby activating AMP-activated prot...

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Bibliographic Details
Main Authors: Jeremi Laski, Bipradeb Singha, Xu Wang, Yudith Ramos Valdés, Olga Collins, Trevor G. Shepherd
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Ovarian Research
Subjects:
High-grade serous ovarian cancer
Spheroid
AMPK
Autophagy
CAMKKβ
STO-609
Online Access:http://link.springer.com/article/10.1186/s13048-020-00660-5

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http://link.springer.com/article/10.1186/s13048-020-00660-5

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