Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages

Shape transformation of proteins created by design in the laboratory is challenging. Here, the authors present a disulfide-mediated approach for the preparation of 16-mer, 24-mer, and 48-mer nanocages from an 8-mer bowl-like protein building block.

Bibliographic Details
Main Authors:	Jiachen Zang, Hai Chen, Xiaorong Zhang, Chenxi Zhang, Jing Guo, Ming Du, Guanghua Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08788-9

id	doaj-d4496bef09364daa81f5f10a6ef0d7ac
record_format	Article
spelling	doaj-d4496bef09364daa81f5f10a6ef0d7ac2021-05-11T12:21:14ZengNature Publishing GroupNature Communications2041-17232019-02-0110111110.1038/s41467-019-08788-9Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocagesJiachen Zang0Hai Chen1Xiaorong Zhang2Chenxi Zhang3Jing Guo4Ming Du5Guanghua Zhao6Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of EducationBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of EducationBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of EducationBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of EducationCenter of Biomedical Analysis, Tsinghua UniversitySchool of Food Science and Technology, National Engineering Research Center of Seafood, Dalian Polytechnic UniversityBeijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Key Laboratory of Functional Dairy, Ministry of EducationShape transformation of proteins created by design in the laboratory is challenging. Here, the authors present a disulfide-mediated approach for the preparation of 16-mer, 24-mer, and 48-mer nanocages from an 8-mer bowl-like protein building block.https://doi.org/10.1038/s41467-019-08788-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jiachen Zang Hai Chen Xiaorong Zhang Chenxi Zhang Jing Guo Ming Du Guanghua Zhao
spellingShingle	Jiachen Zang Hai Chen Xiaorong Zhang Chenxi Zhang Jing Guo Ming Du Guanghua Zhao Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages Nature Communications
author_facet	Jiachen Zang Hai Chen Xiaorong Zhang Chenxi Zhang Jing Guo Ming Du Guanghua Zhao
author_sort	Jiachen Zang
title	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
title_short	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
title_full	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
title_fullStr	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
title_full_unstemmed	Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
title_sort	disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Shape transformation of proteins created by design in the laboratory is challenging. Here, the authors present a disulfide-mediated approach for the preparation of 16-mer, 24-mer, and 48-mer nanocages from an 8-mer bowl-like protein building block.
url	https://doi.org/10.1038/s41467-019-08788-9
work_keys_str_mv	AT jiachenzang disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages AT haichen disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages AT xiaorongzhang disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages AT chenxizhang disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages AT jingguo disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages AT mingdu disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages AT guanghuazhao disulfidemediatedconversionof8merbowllikeproteinarchitectureintothreedifferentnanocages
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Disulfide-mediated conversion of 8-mer bowl-like protein architecture into three different nanocages

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