Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme

PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target PP1 to substrates or subcellular locations, but it remains unclear how they might confer sequence-specificity on PP1. The cytoskeletal regulator Phactr1 is a neuronally enriched PP1 cofactor that is controlle...

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Bibliographic Details
Main Authors: Roman O Fedoryshchak, Magdalena Přechová, Abbey M Butler, Rebecca Lee, Nicola O'Reilly, Helen R Flynn, Ambrosius P Snijders, Noreen Eder, Sila Ultanir, Stephane Mouilleron, Richard Treisman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
Phactr1
Protein Phosphatase 1
RPEL
actin
cytoskeleton
IRSp53
Online Access:https://elifesciences.org/articles/61509

Internet

https://elifesciences.org/articles/61509

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