Functional Annotations of Paralogs: A Blessing and a Curse
Gene duplication followed by mutation is a classic mechanism of neofunctionalization, producing gene families with functional diversity. In some cases, a single point mutation is sufficient to change the substrate specificity and/or the chemistry performed by an enzyme, making it difficult to accura...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2016-09-01
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| Series: | Life |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-1729/6/3/39 |