Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics

Consideration of Metabolite Efflux in Radiolabelled Choline Kinetics

Hypoxia is a complex microenvironmental condition known to regulate choline kinase α (CHKA) activity and choline transport through transcription factor hypoxia-inducible factor-1α (HIF-1α) and, therefore, may confound the uptake of choline radiotracer [<sup>18</sup>F]fluoromethyl-[1,2-&l...

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Bibliographic Details
Main Authors: Yunqing Li, Marianna Inglese, Suraiya Dubash, Chris Barnes, Diana Brickute, Marta Costa Braga, Ning Wang, Alice Beckley, Kathrin Heinzmann, Louis Allott, Haonan Lu, Cen Chen, Ruisi Fu, Laurence Carroll, Eric O. Aboagye
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Pharmaceutics
Subjects:
choline kinase
hypoxia
efflux
Online Access:https://www.mdpi.com/1999-4923/13/8/1246

Internet

https://www.mdpi.com/1999-4923/13/8/1246

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