Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission

Identification of Unequally Represented Founder Viruses Among Tissues in Very Early SIV Rectal Transmission

Characterizing the transmitted/founder (T/F) viruses of multi-variant SIV infection may shed new light on the understanding of mucosal transmission. We intrarectally inoculated six Chinese rhesus macaques with a single high dose of SIVmac251 (3.1 × 104 TCID50) and obtained 985 full-length env sequen...

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Bibliographic Details
Main Authors: Jian Chen, Yanqin Ren, Lance Daharsh, Lu Liu, Guobin Kang, Qingsheng Li, Qiang Wei, Yanmin Wan, Jianqing Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Microbiology
Subjects:
Chinese rhesus macaque
rectal transmission
SIV
transmitted/founder virus
very early virological events
CG dinucleotide
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00557/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00557/full

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