β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

Objective: β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using in vitro and in vivo systems. Methods: We developed a tetracycline-on system of pre-...

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Bibliographic Details
Main Authors: Sara Ibrahim, Macey Johnson, Clarissa Hernandez Stephens, Jerry Xu, Rachel Moore, Andrea Mariani, Christopher Contreras, Farooq Syed, Raghavendra G. Mirmira, Ryan M. Anderson, Emily K. Sims
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
β-cell
Islet
microRNA 21
Dedifferentiation
Identity
β-cell dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001344

Internet

http://www.sciencedirect.com/science/article/pii/S2212877821001344

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