Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling

Kakoki et al report a role for cyanocobalamin (B12) in preventing cardiomyopathy in type 1 diabetic mice, by reducing levels of reactive oxygen species and restoring IGF-1 levels via DNMT-SOCS1/3 signalling. The authors therefore propose B12 as a promising option to prevent diabetic cardiomyopathy t...

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Bibliographic Details
Main Authors: Masao Kakoki, Purushotham V. Ramanathan, John R. Hagaman, Ruriko Grant, Jennifer C. Wilder, Joan M. Taylor, J. Charles Jennette, Oliver Smithies, Nobuyo Maeda-Smithies
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02291-y

Internet

https://doi.org/10.1038/s42003-021-02291-y

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