Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

Hepatitis B virus impairs TLR9 expression and function in plasmacytoid dendritic cells.

Plasmacytoid dendritic cells (pDCs) play a key role in detecting pathogens by producing large amounts of type I interferon (IFN) by sensing the presence of viral infections through the Toll-Like Receptor (TLR) pathway. TLR9 is a sensor of viral and bacterial DNA motifs and activates the IRF7 transcr...

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Bibliographic Details
Main Authors: Isabelle E Vincent, Claudia Zannetti, Julie Lucifora, Helene Norder, Ulrike Protzer, Pierre Hainaut, Fabien Zoulim, Massimo Tommasino, Christian Trépo, Uzma Hasan, Isabelle Chemin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046272/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046272/pdf/?tool=EBI

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