A role for orphan nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) in primordial follicle activation

A role for orphan nuclear receptor liver receptor homolog-1 (LRH-1, NR5A2) in primordial follicle activation

Abstract Liver receptor homolog-1 (NR5A2) is expressed specifically in granulosa cells of developing ovarian follicles where it regulates the late stages of follicle development and ovulation. To establish its effects earlier in the trajectory of follicular development, NR5A2 was depleted from granu...

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Bibliographic Details
Main Authors: Marie-Charlotte Meinsohn, Camilla H. K. Hughes, Anthony Estienne, Hatice D. Saatcioglu, David Pépin, Raj Duggavathi, Bruce D. Murphy
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-80178-4

Internet

https://doi.org/10.1038/s41598-020-80178-4

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