A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica

A 23 bp cyp51A Promoter Deletion Associated With Voriconazole Resistance in Clinical and Environmental Isolates of Neocosmospora keratoplastica

In the fungal pathogen Aspergillus fumigatus, resistance to azole antifungals is often linked to mutations in CYP51A, a gene that encodes the azole antifungal drug target lanosterol 14α-demethylase. The aim of this study was to investigate whether similar changes could be associated with azole resis...

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Bibliographic Details
Main Authors: Jasper Elvin James, Erwin Lamping, Jacinta Santhanam, Trudy Jane Milne, Mohd Fuat Abd Razak, Latiffah Zakaria, Richard David Cannon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Microbiology
Subjects:
azole
Cyp51A
Neocosmospora
Fusarium
FSSC
sterol regulatory element
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00272/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.00272/full

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