Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases.

Currently, only few techniques are available for quantifying systemic metastases in preclinical model. Thus techniques that can sensitively detect metastatic colonization and assess treatment response in real-time are urgently needed. To this end, we engineered tumor cells to express a naturally sec...

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Bibliographic Details
Main Authors: Euiheon Chung, Hiroshi Yamashita, Patrick Au, Bakhos A Tannous, Dai Fukumura, Rakesh K Jain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2789383?pdf=render