A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis

A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis

Accumulated evidence shows that G protein-coupled receptor 119 (GPR119) plays a key role in glucose and lipid metabolism. Here, we explored the effect of GPR119 on cholesterol metabolism and inflammation in THP-1 macrophages and atherosclerotic plaque progression in apoE−/− mice. We found that oxidi...

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Bibliographic Details
Main Authors: Yan-Wei Hu, Jun-Yao Yang, Xin Ma, Zhi-Ping Chen, Ya-Rong Hu, Jia-Yi Zhao, Shu-Fen Li, Yu-Rong Qiu, Jing-Bo Lu, Yan-Chao Wang, Ji-Juan Gao, Yan-Hua Sha, Lei Zheng, Qian Wang
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Journal of Lipid Research
Subjects:
long intervening noncoding ribonucleic acid-DYNLRB2-2
G protein-coupled receptor 119
glucagon-like peptide 1 receptor
ATP binding cassette transporter A1
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520376574

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http://www.sciencedirect.com/science/article/pii/S0022227520376574

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