Alloantigen-activated (AAA) CD4+ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice

Alloantigen-activated (AAA) CD4+ T cells reinvigorate host endogenous T cell immunity to eliminate pre-established tumors in mice

Abstract Background Cancer vaccines that induce endogenous antitumor immunity represent an ideal strategy to overcome intractable cancers. However, doing this against a pre-established cancer using autologous immune cells has proven to be challenging. “Allogeneic effects” refers to the induction of...

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Bibliographic Details
Main Authors: Kazuhiro Mochizuki, Shogo Kobayashi, Nobuhisa Takahashi, Kotaro Sugimoto, Hideki Sano, Yoshihiro Ohara, Shin Mineishi, Yi Zhang, Atsushi Kikuta
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer immunotherapy
Cancer vaccine
Allogeneic CD4+ T-cell
Endogenous CD8+ cytotoxic T-cell
Dendritic cell
Online Access:https://doi.org/10.1186/s13046-021-02102-6

Internet

https://doi.org/10.1186/s13046-021-02102-6

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