Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases

Cell Shape and Matrix Stiffness Impact Schwann Cell Plasticity via YAP/TAZ and Rho GTPases

Schwann cells (SCs) are a highly plastic cell type capable of undergoing phenotypic changes following injury or disease. SCs are able to upregulate genes associated with nerve regeneration and ultimately achieve functional recovery. During the regeneration process, the extracellular matrix (ECM) and...

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Bibliographic Details
Main Authors: Zhenyuan Xu, Jacob A. Orkwis, Greg M. Harris
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
Schwann cell
mechanobiology
Rho GTPase
YAP/TAZ
extracellular matrix
peripheral nerve
Online Access:https://www.mdpi.com/1422-0067/22/9/4821

Internet

https://www.mdpi.com/1422-0067/22/9/4821

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