Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice

Increased Hypothalamic Anti-Inflammatory Mediators in Non-Diabetic Insulin Receptor Substrate 2-Deficient Mice

Insulin receptor substrate (IRS) 2 is a key mediator of insulin signaling and IRS-2 knockout (IRS2<sup>−/−</sup>) mice are a preclinical model to study the development of diabetes, as they develop peripheral insulin resistance and beta-cell failure. The differential inflammatory profile...

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Bibliographic Details
Main Authors: María Vinaixa, Sandra Canelles, África González-Murillo, Vítor Ferreira, Diana Grajales, Santiago Guerra-Cantera, Ana Campillo-Calatayud, Manuel Ramírez-Orellana, Óscar Yanes, Laura M. Frago, Ángela M. Valverde, Vicente Barrios
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
diabetes
hypothalamus
inflammation
IRS2<sup>−/−</sup> mice
PUFA
Online Access:https://www.mdpi.com/2073-4409/10/8/2085

Internet

https://www.mdpi.com/2073-4409/10/8/2085

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