Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs

Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs

<p>Abstract</p> <p>Background</p> <p>Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is widely used for quantitative proteomic investigations. The typical output of such studies is a list of identified and quantified peptides. The biological and c...

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Bibliographic Details
Main Authors: Clough Timothy, Thaminy Safia, Ragg Susanne, Aebersold Ruedi, Vitek Olga
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Bioinformatics
Subjects:
Label-free LC-MS/MS
linear mixed effects models
protein quantification
quantitative proteomics
statistical design of experiments
Online Access:http://www.biomedcentral.com/1471-2105/13/S16/S6

Internet

http://www.biomedcentral.com/1471-2105/13/S16/S6

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