Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice.

Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice.

Several reports indicate that melatonin alleviates bleomycin (BLM)-induced pulmonary fibrosis in rodent animals. Nevertheless, the exact mechanism remains obscure. The present study investigated the effects of melatonin on endoplasmic reticulum (ER) stress and epithelial-mesenchymal transition (EMT)...

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Bibliographic Details
Main Authors: Hui Zhao, Qing-Qing Wu, Lin-Feng Cao, Hou-Ying Qing, Cheng Zhang, Yuan-Hua Chen, Hua Wang, Rong-Ru Liu, De-Xiang Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4018327?pdf=render

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http://europepmc.org/articles/PMC4018327?pdf=render

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