Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke

Inhibition of PDE1-B by Vinpocetine Regulates Microglial Exosomes and Polarization Through Enhancing Autophagic Flux for Neuroprotection Against Ischemic Stroke

Exosomes contribute to cell–cell communications. Emerging evidence has shown that microglial exosomes may play crucial role in regulation of neuronal functions under ischemic conditions. However, the underlying mechanisms of microglia-derived exosome biosynthesis are largely unknown. Herein, we repo...

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Bibliographic Details
Main Authors: Jiankun Zang, Yousheng Wu, Xuanlin Su, Tianyuan Zhang, Xionglin Tang, Dan Ma, Yufeng Li, Yanfang Liu, Ze’an Weng, Xuanzhuo Liu, Chi Kwan Tsang, Anding Xu, Dan Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
BV2
OGD
PDE1
vinpocetine
autophagy
exosome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.616590/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.616590/full

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