PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment

PD-L1 is not constitutively expressed on Tasmanian devil facial tumor cells but is strongly upregulated in response to IFN-γ and can be expressed in the tumor microenvironment

The devil facial tumor disease (DFTD) is caused by clonal transmissible cancers that have led to a catastrophic decline in the wild Tasmanian devil (Sarcophilus harrisii) population. The first transmissible tumor, now termed DFT1, was first discovered in 1996 and has been continually transmitted to...

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Bibliographic Details
Main Authors: Andrew Steven Flies, Alan Bruce Lyons, Lynn M Corcoran, Anthony T Papenfuss, James M Murphy, Graeme W Knowles, Greg M Woods, John Dominic Hayball
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
Immunotherapy
Vaccines
Cancer
marsupial
allograft rejection
PD-1
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00581/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00581/full

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