The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

The Chemokine CCL2 Increases Prostate Tumor Growth and Bone Metastasis through Macrophage and Osteoclast Recruitment

CC chemokine ligand 2 (CCL2, also known as monocyte chemoattractant protein-1) has been demonstrated to recruit monocytes to tumor sites. Monocytes are capable of being differentiated into tumor-associated macrophages (TAMs) and osteoclasts (OCs). TAMs have been shown to promote tumor growth in sev...

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Bibliographic Details
Main Authors: Kosuke Mizutani, Sudha Sud, Natalie A. McGregor, Gari Martinovski, Brandon T. Rice, Matthew J. Craig, Zachary S. Varsos, Hernan Roca, Kenneth J. Pienta
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860980081X

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http://www.sciencedirect.com/science/article/pii/S147655860980081X

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