N-substituted benzyl matrinic acid derivatives inhibit hepatitis C virus (HCV) replication through down-regulating host heat-stress cognate 70 (Hsc70) expression.

N-substituted benzyl matrinic acid derivatives inhibit hepatitis C virus (HCV) replication through down-regulating host heat-stress cognate 70 (Hsc70) expression.

Heat-stress cognate 70 (Hsc70) is a host factor that helps hepatitis C virus (HCV) to complete its life cycle in infected hepatocytes. Using Hsc70 as a target for HCV inhibition, a series of novel N-substituted benzyl matrinic/sophoridinic acid derivatives was synthesized and evaluated for their ant...

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Bibliographic Details
Main Authors: Na-Na Du, Zong-Gen Peng, Chong-Wen Bi, Sheng Tang, Ying-Hong Li, Jian-Rui Li, Yan-Ping Zhu, Jing-Pu Zhang, Yan-Xiang Wang, Jian-Dong Jiang, Dan-Qing Song
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3597726?pdf=render

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http://europepmc.org/articles/PMC3597726?pdf=render

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