Up-regulation of PKR pathway contributes to L-NAME induced hypertension and renal damage

Objective: Hypertension induced kidney damage is often associated with fibrosis and tubular apoptosis. Double-stranded protein kinase (PKR) is a well recognized inducer of inflammation and apoptosis. However, role of PKR in hypertension coupled renal damage is still not explored. Therefore here we s...

Full description

Bibliographic Details
Main Authors: Jaspreet Kalra, Audesh Bhat, KirtiKumar B Jadhav, Arti Dhar
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Heliyon
Subjects:
PKR
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020323069