Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations

Abstract Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here we studied the differences and commonalities between the transcriptome...

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Bibliographic Details
Main Authors: Janne Koskimäki, Dongdong Zhang, Yan Li, Laleh Saadat, Thomas Moore, Rhonda Lightle, Sean P. Polster, Julián Carrión-Penagos, Seán B. Lyne, Hussein A. Zeineddine, Changbin Shi, Robert Shenkar, Sharbel Romanos, Kenneth Avner, Abhinav Srinath, Le Shen, Matthew R. Detter, Daniel Snellings, Ying Cao, Miguel A. Lopez-Ramirez, Gregory Fonseca, Alan T. Tang, Pieter Faber, Jorge Andrade, Mark Ginsberg, Mark L. Kahn, Douglas A. Marchuk, Romuald Girard, Issam A. Awad
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Acta Neuropathologica Communications
Subjects:
Cerebral cavernous malformation
Cavernous angioma
Hemangioma
Ccm3
Mouse model
Transcriptome
Online Access:http://link.springer.com/article/10.1186/s40478-019-0789-0

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http://link.springer.com/article/10.1186/s40478-019-0789-0

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