Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis

Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis

Osteoarthritis (OA), which is the most common degenerative joint disorder, has been considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a pleiotropic cytokine involved in inflammatory diseases and their production is driven by the cytokine including IL-1 and IL-23....

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Bibliographic Details
Main Authors: Hyun Sik Na, Jin-Sil Park, Keun-Hyung Cho, Ji Ye Kwon, JeongWon Choi, Jooyeon Jhun, Seok Jung Kim, Sung-Hwan Park, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
inflammation
interleukin-17
IL-1 receptor antagonist knockout
intestinal homeostasis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00730/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00730/full

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