Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation

Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation

Abstract Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis due to limited therapeutic options. This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets. We have identified HNF4G gene whose silencing most effectively repressed PDA...

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Bibliographic Details
Main Authors: Chengcheng Wang, Taiping Zhang, Quan Liao, Menghua Dai, Junchao Guo, Xinyu Yang, Wen Tan, Dongxin Lin, Chen Wu, Yupei Zhao
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:Protein & Cell
Subjects:
pancreatic cancer
HNF4G
SMAD4 deficiency
SMAD4-deficient PDAC
Metformin
Online Access:https://doi.org/10.1007/s13238-020-00760-4

Internet

https://doi.org/10.1007/s13238-020-00760-4

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