The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

The Selective Class IIa Histone Deacetylase Inhibitor TMP195 Resensitizes ABCB1- and ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Cytotoxic Anticancer Drugs

Multidrug resistance caused by the overexpression of the ATP-binding cassette (ABC) proteins in cancer cells remains one of the most difficult challenges faced by drug developers and clinical scientists. The emergence of multidrug-resistant cancers has driven efforts from researchers to develop inno...

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Bibliographic Details
Main Authors: Chung-Pu Wu, Sabrina Lusvarghi, Jyun-Cheng Wang, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Suresh V. Ambudkar
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:International Journal of Molecular Sciences
Subjects:
tmp195
histone deacetylase inhibitor
chemoresistance
modulators
p-glycoprotein
breast cancer resistance protein
Online Access:https://www.mdpi.com/1422-0067/21/1/238

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https://www.mdpi.com/1422-0067/21/1/238

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