Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages

Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages

Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E2 (PGE2). However, it has been described that dermal fibroblasts behave like mesenchymal stem cells reducing lymphocyte recruitment and dendr...

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Bibliographic Details
Main Authors: Jorge Arasa, María Carmen Terencio, Rosa María Andrés, Asunción Marín-Castejón, Francisca Valcuende-Cavero, Miguel Payá, María Carmen Montesinos
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
cyclooxygenase
fibroblasts
psoriasis
macrophages
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00536/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00536/full

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