Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

The innate immune system is the first line of defense against Neisseria gonorrhoeae (GC). Exposure of cells to GC lipooligosaccharides induces a strong immune response, leading to type I interferon (IFN) production via TLR4/MD-2. In addition to living freely in the extracellular space, GC can invade...

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Bibliographic Details
Main Authors: Warrison A. Andrade, Sarika Agarwal, Shunyan Mo, Scott A. Shaffer, Joseph P. Dillard, Tobias Schmidt, Veit Hornung, Katherine A. Fitzgerald, Evelyn A. Kurt-Jones, Douglas T. Golenbock
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
type I interferon
cGAS
STING
TLR4
Neisseria gonorrhoeae
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306131

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716306131

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