Elevated intracardiac angiotensin II leads to cardiac hypertrophy and mechanical dysfunction in normotensive mice

Introduction Angiotensin II (Ang II) is known to induce cardiac growth and modulate myocardial contractility. It has been reported that elevated levels of endogenous Ang II contribute to the development of cardiac hypertrophy in hypertensives. However, the long-term functional effects of cardiac exp...

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Bibliographic Details
Main Authors: Catherine E Huggins, Andrea A Domenighetti, Thierry Pedrazzini, Salvatore Pepe, Lea MD Delbridge
Format: Article
Language:English
Published: Hindawi - SAGE Publishing 2003-09-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2003.030