Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and L-NAME-Induced Hypertensive Rats

Blockade of Rostral Ventrolateral Medulla Apelin Receptors Does Not Attenuate Arterial Pressure in SHR and L-NAME-Induced Hypertensive Rats

Dysfunction of the apelinergic system, comprised of the neuropeptide apelin mediating its effects via the G protein-coupled apelin receptor (APJ), may underlie the onset of cardiovascular disease such as hypertension. Apelin expression is increased in the rostral ventrolateral medulla (RVLM) in spon...

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Bibliographic Details
Main Authors: Philip R. Griffiths, Stephen J. Lolait, Louise E. Pearce, Fiona D. McBryde, Julian F. R. Paton, Anne-Marie O’Carroll
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
apelin receptor
apelin
blood pressure
rostral ventrolateral medulla
hypertensive rats
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01488/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01488/full

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