Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Tofacitinib Loaded Squalenyl Nanoparticles for Targeted Follicular Delivery in Inflammatory Skin Diseases

Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB’s safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparticles...

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Bibliographic Details
Main Authors: Rebekka Christmann, Duy-Khiet Ho, Jenny Wilzopolski, Sangeun Lee, Marcus Koch, Brigitta Loretz, Thomas Vogt, Wolfgang Bäumer, Ulrich F. Schaefer, Claus-Michael Lehr
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceutics
Subjects:
targeted drug delivery
hair follicle
<i>in vivo</i> allergic dermatitis mouse model
follicular delivery
interfollicular delivery
nanoparticles
Online Access:https://www.mdpi.com/1999-4923/12/12/1131

Internet

https://www.mdpi.com/1999-4923/12/12/1131

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