Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.

Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.

Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in different temporal stages of development, combined with...

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Bibliographic Details
Main Authors: Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237773

Internet

https://doi.org/10.1371/journal.pone.0237773

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