The IL-6 antagonist tocilizumab is associated with worse depression and related symptoms in the medically ill

The IL-6 antagonist tocilizumab is associated with worse depression and related symptoms in the medically ill

Abstract Because medical illness is associated with increased inflammation and an increased risk for treatment-resistant major depressive disorder, anti-cytokine therapy may represent a novel, and especially efficacious, treatment for depression. We hypothesized that blockade of the interleukin (IL)...

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Bibliographic Details
Main Authors: Jennifer M. Knight, Erin S. Costanzo, Suraj Singh, Ziyan Yin, Aniko Szabo, Deepa S. Pawar, Cecilia J. Hillard, J. Douglas Rizzo, Anita D’Souza, Marcelo Pasquini, Christopher L. Coe, Michael R. Irwin, Charles L. Raison, William R. Drobyski
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01164-y

Internet

https://doi.org/10.1038/s41398-020-01164-y

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