Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs

Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs

Abstract Background Sildenafil citrate, a highly selective phosphodiesterase type 5 inhibitor, is used to treat pulmonary hypertension (PH) in veterinary medicine. The objective of this study was to investigate pharmacokinetic profiles by oral administration of orally disintegrating film (ODF) and f...

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Bibliographic Details
Main Authors: Hyuck-Joo Yang, Ye-In Oh, Jong-Woo Jeong, Kun-Ho Song, Tae-Sung Koo, Kyoung-Won Seo
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Veterinary Research
Subjects:
Dog
Orally disintegrating film formulation
Rectal administration
Sildenafil
Pulmonary hypertension
Online Access:http://link.springer.com/article/10.1186/s12917-018-1617-7

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http://link.springer.com/article/10.1186/s12917-018-1617-7

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