The grafting of universal T-helper epitopes enhances immunogenicity of HIV-1 Tat concurrently improving its safety profile.

The grafting of universal T-helper epitopes enhances immunogenicity of HIV-1 Tat concurrently improving its safety profile.

Extracellular Tat (eTat) plays an important role in HIV-1 pathogenesis. The presence of anti-Tat antibodies is negatively correlated with disease progression, hence making Tat a potential vaccine candidate. The cytotoxicity and moderate immunogenicity of Tat however remain impediments for developing...

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Bibliographic Details
Main Authors: Venkatesh P Kashi, Rajesh A Jacob, Raghavendra A Shamanna, Malini Menon, Anangi Balasiddaiah, Rebu K Varghese, Mahesh Bachu, Udaykumar Ranga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4273983?pdf=render

Internet

http://europepmc.org/articles/PMC4273983?pdf=render

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