Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

Microglial physiological properties and interactions with synapses are altered at presymptomatic stages in a mouse model of Huntington’s disease pathology

Abstract Background Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation elongating the CAG repeats within the Huntingtin gene, resulting in HTT pr...

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Bibliographic Details
Main Authors: Julie C. Savage, Marie-Kim St-Pierre, Micaël Carrier, Hassan El Hajj, Sammy Weiser Novak, Maria Gabriela Sanchez, Francesca Cicchetti, Marie-Ève Tremblay
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Huntington’s disease
Electron microscopy
Phagocytosis
Synapses
Online Access:http://link.springer.com/article/10.1186/s12974-020-01782-9

Internet

http://link.springer.com/article/10.1186/s12974-020-01782-9

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