Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

Platycodon grandiflorum Saponins Ameliorate Cisplatin-Induced Acute Nephrotoxicity through the NF-κB-Mediated Inflammation and PI3K/Akt/Apoptosis Signaling Pathways

Although cisplatin is a potent chemotherapeutic agent against cancers, its clinical application is seriously limited by its severe side effects of nephrotoxicity. Previous studies reported that saponins isolated from the roots of Platycodon grandiflorum (PGS) exerted protective effects in various an...

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Bibliographic Details
Main Authors: Weizhe Zhang, Jingang Hou, Xiaotong Yan, Jing Leng, Rongyan Li, Jing Zhang, Jingjing Xing, Chen Chen, Zi Wang, Wei Li
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Nutrients
Subjects:
Platycodon grandiflorum saponins
cisplatin
nephrotoxicity
NF-κB
PI3K/Akt/Apoptosis
inflammation
Online Access:http://www.mdpi.com/2072-6643/10/9/1328

Internet

http://www.mdpi.com/2072-6643/10/9/1328

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