A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes

A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes

The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for embryonic development. It mediates the base excision repair (BER) of G:T and G:U DNA mismatches arising from the deamination of 5-methyl cytosine (5-MeC) and cytosine, respectively. Recent studies have pointed at a...

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Bibliographic Details
Main Authors: Hélène Léger, Caroline Smet-Nocca, Amel Attmane-Elakeb, Sara Morley-Fletcher, Arndt G. Benecke, Sebastian Eilebrecht
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
CREB-binding protein
Thymine DNA glycosylase
Retinoic acid receptor α
Transcription regulation
Cytosine DNA methylation
Epigenomics
Online Access:http://www.sciencedirect.com/science/article/pii/S1672022913001393

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http://www.sciencedirect.com/science/article/pii/S1672022913001393

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