Adenosine deaminase deficiency: a review

Adenosine deaminase deficiency: a review

Abstract Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation by-products, most potently affecting lymphocytes, leading to adenosine deaminase-deficient severe combined immunodeficiency. Whilst most notable affects are on lymphocytes, other manifestations include...

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Bibliographic Details
Main Authors: Aisling M. Flinn, Andrew R. Gennery
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Adenosine deaminase
Severe combined immunodeficiency
Neurodevelopment
Haematopoietic stem cell transplantation
Gene therapy
Pulmonary alveolar proteinosisis
Online Access:http://link.springer.com/article/10.1186/s13023-018-0807-5

Internet

http://link.springer.com/article/10.1186/s13023-018-0807-5

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