PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination.

PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination.

Meiotic recombination generates new genetic variation and assures the proper segregation of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase activity, initiates meiotic recombination by binding DNA at recombination hotspots and directing the position of DNA double-...

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Bibliographic Details
Main Authors: Christopher L Baker, Shimpei Kajita, Michael Walker, Ruth L Saxl, Narayanan Raghupathy, Kwangbom Choi, Petko M Petkov, Kenneth Paigen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4287450?pdf=render

Internet

http://europepmc.org/articles/PMC4287450?pdf=render

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