Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma.

Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma.

Ror2 is a Wnt ligand receptor that is overexpressed in a variety of tumors including clear cell renal cell carcinoma (ccRCC). Here we demonstrate that expression of wild type Ror2 results in increased tumorigenic properties in in vitro cell culture and in vivo xenograft models. In addition, Ror2 exp...

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Bibliographic Details
Main Authors: Neal R Rasmussen, Zufan Debebe, Tricia M Wright, Samira A Brooks, Adam B Sendor, A Rose Brannon, A Ari Hakimi, James J Hsieh, Toni K Choueiri, Pheroze Tamboli, Jodi K Maranchie, Peter Hinds, Eric M Wallen, Catherine Simpson, Jacqueline L Norris, William P Janzen, W Kimryn Rathmell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4277431?pdf=render

Internet

http://europepmc.org/articles/PMC4277431?pdf=render

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