Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis

EGFR signalling has been linked to cancer development but whether it has any role in pre-metastatic niche formation is not known. Here the authors show that gastric cancer cells send EGFR through exosomes to the liver where it causes the establishment of a favourable microenvironment thus promoting...

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Bibliographic Details
Main Authors: Haiyang Zhang, Ting Deng, Rui Liu, Ming Bai, Likun Zhou, Xia Wang, Shuang Li, Xinyi Wang, Haiou Yang, Jialu Li, Tao Ning, Dingzhi Huang, Hongli Li, Le Zhang, Guoguang Ying, Yi Ba
Format: Article
Language:English
Published: Nature Publishing Group 2017-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15016

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https://doi.org/10.1038/ncomms15016

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